Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible. Here. we identify sphingomyelin phosphodiesterase 1 (SMPD1). an enzyme that regulates the conversion of sphingomyelin to ceramide. https://www.inmuebleslasmercedes.com/product-category/insulated-dinnerware/