A variety of circumstantial evidence from humans has implicated the B cell antigen receptor (BCR) in the genesis of B cell lymphomas. We generated mouse models designed to test this possibility directly. and we found that both the constitutive and antigen-stimulated state of a clonal BCR affected the rate and outcome of lymphomagenesis initiated by the proto-oncogene MYC. The tumors t... https://www.marcelovicente.com/product-category/pre-shampoo-treatment/
The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas.
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