In 1948 a corticosteroid compound was administered for the first time to a patient affected by rheumatoid arthritis by Philip Showalter Hench. a rheumatologist at the Mayo Clinic in Rochester. Minnesota (USA). He was investigating since 1929 the role of adrenal gland-derived substances in rheumatoid arthritis. https://www.marcelovicente.com/product-category/6-19-c/